Allergy treatments

In recent years, new biologic injection medications have become available under insurance coverage in Japan for treating severe atopic dermatitis and chronic urticaria (hives).
These treatments can be effective for patients who did not respond sufficiently to topical steroids or oral medications.

• Dupixent (Dupilumab) — Approved for moderate to severe atopic dermatitis, chronic urticaria, and prurigo nodularis.
　Helps reduce itching and eczema.
　Injections are administered every 2 weeks or once per month, depending on age and body weight.
　Suitable for patients as young as 6 months old.

• Xolair (Omalizumab) — Used when chronic urticaria cannot be controlled with antihistamines.
　Administered once per month.
　Other biologics such as Ebglyss and Adtralza are also available at our clinic — please contact us for more details.

• These medications are covered by Japanese National Health Insurance, depending on severity and treatment history.

• Some patients can perform self-injections at home, reducing the need for frequent clinic visits.

• In some cases, biologics allow for reduction or discontinuation of oral medications.
　Our clinic provides comprehensive support, from verifying insurance eligibility to introducing treatment and guiding patients in safe self-administration.

Please consult your doctor to discuss suitability.

What is Histaglobin?
Histaglobin® is an allergy-modulating injection designed to improve allergic sensitivity and immune balance.
It combines a small amount of histamine with human immunoglobulin, helping regulate excessive immune reactions.
Unlike antihistamines or steroids that suppress symptoms temporarily, Histaglobin aims to improve the underlying allergic tendency itself.

Histaglobin injection is covered under NHI for the following:
• Bronchial asthma
• Allergic rhinitis (including hay fever and perennial allergies)
• Chronic urticaria (hives)
• Eczema and dermatitis (including atopic dermatitis)

𝗛𝗼𝘄 𝗜𝘁 𝗪𝗼𝗿𝗸𝘀
Histaglobin is not allergen-specific; it does not target one particular allergen like pollen or dust.
Instead, it helps improve the overall immune balance, regardless of the allergen type.
It can be effective for a wide range of triggers, including:
• Pollen (cedar, cypress, ragweed, etc.)
• Dust mites and house dust
• Animal dander
• Skin symptoms related to food or medication allergies
• Chronic hives of unknown cause (idiopathic urticaria)

💡 Unlike sublingual immunotherapy, which targets a specific allergen, Histaglobin aims to regulate general allergic reactivity across multiple causes.

• Frequency: 1–2 injections per week for several weeks.
• Effect: Gradual improvement; the goal is to reduce symptom severity over time, not immediate relief.
• Side effects: Mild redness or fatigue at the injection site may occur but are usually temporary and mild.

• Patients whose hay fever symptoms remain strong despite medication.
• Those with chronic hives or persistent itching.
• Patients with recurrent atopic dermatitis.
• People seeking to improve their allergic constitution rather than only treat symptoms.

Histaglobin injection is an NHI covered therapy that helps regulate the immune system’s overreaction to allergens.
It offers a broad-spectrum approach for patients with hay fever, hives, or atopic dermatitis who wish to strengthen overall allergy resistance.

𝗖𝗶𝗱𝗮𝗰𝘂𝗿𝗲® (𝗖𝗲𝗱𝗮𝗿 𝗣𝗼𝗹𝗹𝗲𝗻 𝗧𝗮𝗯𝗹𝗲𝘁)
• Target: Cedar pollen allergy — the most common cause of hay fever in Japan.
• Composition: Extract of cedar pollen allergen.
• Start Period: Recommended to begin during non-pollen season (June–December).
• Effect: Reduces sneezing, runny nose, and itchy eyes; may lower the risk of new allergies and asthma development.

𝗠𝗶𝘁𝗶𝗰𝘂𝗿𝗲® (𝗗𝘂𝘀𝘁 𝗠𝗶𝘁𝗲 𝗧𝗮𝗯𝗹𝗲𝘁)
• Target: Dust mite-induced perennial allergic rhinitis.
• Composition: Extract of Dermatophagoides farinae and pteronyssinus dust mites.
• Start Period: Can be started any time of the year.
• Effect: Reduces nasal congestion, sneezing, and runny nose by building tolerance to dust mite allergens.

Identify the causative allergen (cedar or dust mite) through allergy testing.
Place the tablet under the tongue for one minute, then swallow.
Take the medication once daily, continuing for at least 3 years for long-term immune retraining.
Noticeable improvement typically appears after 1 year, stabilizing by the 2nd or 3rd year.

• Temporary oral itching, throat discomfort, or mild swelling may occur.
• Severe allergic reactions (anaphylaxis) are extremely rare but possible; the first dose must be taken in a medical setting.

• Cidacure® — Approved for cedar pollen allergy.
• Miticure® — Approved for dust mite allergic rhinitis.
• Applicable for children aged 5 years and older as well as adults.

• Consultation and instructions available in both Japanese and English.
• Identification of allergen triggers using the latest testing methods.
• Ongoing follow-up and reminder system to support consistent long-term treatment.

💡 Sublingual immunotherapy is not a medication that simply suppresses symptoms — it is a treatment designed to reprogram the immune system.
If you suffer from recurring seasonal or year-round allergies, please consult our clinic to explore this option.